{
    "id": 14463,
    "date": "2026-06-02T13:50:25",
    "date_gmt": "2026-06-02T11:50:25",
    "guid": {
        "rendered": "https:\/\/www.alivitpharm.com\/?page_id=14463"
    },
    "modified": "2026-06-03T09:59:11",
    "modified_gmt": "2026-06-03T07:59:11",
    "slug": "epigallocatechin-gallate",
    "status": "publish",
    "type": "page",
    "link": "https:\/\/www.alivitpharm.com\/en\/epigallocatechin-gallate\/",
    "title": {
        "rendered": "Epigallocatechin Gallate"
    },
    "content": {
        "rendered": "<div data-elementor-type=\"wp-page\" data-elementor-id=\"14463\" class=\"elementor elementor-14463\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fe54679 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fe54679\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c5bdc82\" data-id=\"c5bdc82\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-06293a7 elementor-widget elementor-widget-heading\" data-id=\"06293a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Epigallocatechin Gallate<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51058fd elementor-widget elementor-widget-image\" data-id=\"51058fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.alivitpharm.com\/wp-content\/uploads\/2022\/10\/pill.png\" title=\"pill\" alt=\"Pill\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f4557e elementor-widget elementor-widget-text-editor\" data-id=\"4f4557e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Epigallocatechin-3-Gallate<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9d98309 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9d98309\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0404c90\" data-id=\"0404c90\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f315389 elementor-widget elementor-widget-text-editor\" data-id=\"f315389\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\"><strong>Epigallocatechin gallate (EGCG)<\/strong> is the main catechin in green tea with antioxidant and potential chemopreventive properties (prevents the development of malignant diseases).<\/span><\/span><\/p><p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\"><strong> What is EGCG?<\/strong>\u00a0EGCG is the main catechin found in green tea <em>(Camellia sinensis)<\/em>.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Green tea polyphenols (flavonoids), including EGCG, have antioxidant activity, reduce oxidative DNA damage, and inhibit the formation of carcinogens (e.g., nitrosamines).<\/span><\/span><\/p><p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\"><strong>Metabolic and glycemic effects:<\/strong> A 2025 systematic review\/meta-analysis of 41 randomized controlled trials found that EGCG supplementation resulted in modest reductions in fasting blood glucose and HbA1c. <\/span><\/span><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">The effect on fasting insulin was not significant, and the overall improvement in glycemic control was assessed as unlikely to be clinically meaningful as a stand-alone intervention for most populations.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b3bb1b elementor-widget elementor-widget-image\" data-id=\"0b3bb1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.alivitpharm.com\/wp-content\/uploads\/2022\/09\/leaves.png\" title=\"leaves\" alt=\"Leaves\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad0bc95 elementor-widget elementor-widget-text-editor\" data-id=\"ad0bc95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\"><strong>Oncology and radioprotective data:<\/strong> Green tea \/ EGCG is being investigated for cancer prevention, with possible benefit in preventing some types of cancer (bladder, esophageal, pancreatic).<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">A large randomized controlled trial of green tea extract standardized to 150 mg EGCG twice daily for 3 years in 879 patients with prior colorectal adenomas showed a nonsignificant reduction in adenoma recurrence.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">In a mouse model and a cohort of patients undergoing radiotherapy, oral EGCG prophylaxis reduced radiation-induced intestinal damage associated with modulation of the gut microbiota.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">In a double-blind study of postoperative breast radiotherapy, topical application of an EGCG solution to the radiation field reduced radiation dermatitis and lowered the symptom index.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Treatment-related adverse events were limited to stinging and itching.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Green tea preparations are promoted for cancer prevention, cognitive enhancement, heart disease prevention, Parkinson&#8217;s disease prevention, hypercholesterolemia, weight loss, and other conditions;<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">overall rated as &#8220;possibly effective&#8221; for the listed uses.<\/span><\/span><\/p><p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\"><strong>Adverse Effects and Safety Considerations:<\/strong> Most safety data comes from green tea products (containing EGCG plus caffeine and other ingredients); reported adverse effects include agitation, anxiety, arrhythmias, insomnia, palpitations, tachycardia, gastrointestinal upset, hepatotoxicity, hypertension, hyperglycemia, elevated cholesterol, tremor, and dependence\/withdrawal, among others.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Caution is advised in patients with anxiety disorders, heart disease\/arrhythmias, depression, diabetes mellitus, hypertension, renal disease, and peptic ulcer disease.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Use of green tea products is not recommended during pregnancy and lactation due to lack of data.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0fa3d1 elementor-widget elementor-widget-heading\" data-id=\"f0fa3d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">References<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-528cc14 elementor-widget elementor-widget-text-editor\" data-id=\"528cc14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40885603\/\" target=\"_blank\" rel=\"noopener\">Effect of Epigallocatechin Gallate on Glycemic Index: A Systematic Review and Meta-Analysis of Randomized Controlled Trials<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35213393\/\" target=\"_blank\" rel=\"noopener\">Green Tea Extract to Prevent Colorectal Adenomas, Results of a Randomized, Placebo-Controlled Clinical Trial<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39486483\/\" target=\"_blank\" rel=\"noopener\">EGCG protects intestines of mice and pelvic cancer patients against radiation injury via the gut microbiota\/D-tagatose\/AMPK axis<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35648426\/\" target=\"_blank\" rel=\"noopener\">Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/reference.medscape.com\/drug\/camellia-sinensis-camellia-thea-green-tea-344486#4\" target=\"_blank\" rel=\"noopener\">Green Tea (Camellia Sinensis, Camellia Thea, Chinese Tea Green Tea In Combination) &#8211; Adverse Effects<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/reference.medscape.com\/drug\/camellia-sinensis-camellia-thea-green-tea-344486#10\" target=\"_blank\" rel=\"noopener\">Green Tea (Camellia Sinensis, Camellia Thea, Chinese Tea Green Tea In Combination) &#8211; Pharmacology<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/reference.medscape.com\/drug\/camellia-sinensis-camellia-thea-green-tea-344486#2\" target=\"_blank\" rel=\"noopener\">Green Tea (Camellia Sinensis, Camellia Thea, Chinese Tea Green Tea In Combination) &#8211; Suggested Uses<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/reference.medscape.com\/drug\/camellia-sinensis-camellia-thea-green-tea-344486?_gl=1*1gfrlj9*_gcl_au*MTI2MjgxNTQ1OS4xNzc2MTg4MjEx#5\" target=\"_blank\" rel=\"noopener\">Green Tea (Camellia Sinensis, Camellia Thea, Chinese Tea Green Tea In Combination) &#8211; Warnings<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/reference.medscape.com\/drug\/camellia-sinensis-camellia-thea-green-tea-344486#6\" target=\"_blank\" rel=\"noopener\">Green Tea (Camellia Sinensis, Camellia Thea, Chinese Tea Green Tea In Combination) &#8211; Pregnancy &amp; Lactation<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/reference.medscape.com\/drug\/camellia-sinensis-camellia-thea-green-tea-344486#0\" target=\"_blank\" rel=\"noopener\">Green Tea (Camellia Sinensis, Camellia Thea, Chinese Tea Green Tea In Combination) &#8211; Suggested Dosing<\/a><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>",
        "protected": false
    },
    "excerpt": {
        "rendered": "<p>Epigallocatechin Gallate Epigallocatechin-3-Gallate Epigallocatechin gallate (EGCG) is the main catechin in green tea with antioxidant and potential chemopreventive properties (prevents the development of malignant diseases). What is EGCG?\u00a0EGCG is the main catechin found in green tea (Camellia sinensis). Green tea polyphenols (flavonoids), including EGCG, have antioxidant activity, reduce oxidative DNA damage, and inhibit the formation &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/www.alivitpharm.com\/en\/epigallocatechin-gallate\/\"> <span class=\"screen-reader-text\">Epigallocatechin Gallate<\/span> Read More &raquo;<\/a><\/p>",
        "protected": false
    },
    "author": 9,
    "featured_media": 0,
    "parent": 0,
    "menu_order": 0,
    "comment_status": "closed",
    "ping_status": "closed",
    "template": "",
    "meta": {
        "site-sidebar-layout": "no-sidebar",
        "site-content-layout": "page-builder",
        "ast-global-header-display": "",
        "ast-main-header-display": "",
        "ast-hfb-above-header-display": "",
        "ast-hfb-below-header-display": "",
        "ast-hfb-mobile-header-display": "",
        "site-post-title": "disabled",
        "ast-breadcrumbs-content": "",
        "ast-featured-img": "disabled",
        "footer-sml-layout": "",
        "theme-transparent-header-meta": "",
        "adv-header-id-meta": "",
        "stick-header-meta": "",
        "header-above-stick-meta": "",
        "header-main-stick-meta": "",
        "header-below-stick-meta": "",
        "footnotes": ""
    },
    "class_list": [
        "post-14463",
        "page",
        "type-page",
        "status-publish",
        "hentry"
    ],
    "_links": {
        "self": [
            {
                "href": "https:\/\/www.alivitpharm.com\/en\/wp-json\/wp\/v2\/pages\/14463",
                "targetHints": {
                    "allow": [
                        "GET"
                    ]
                }
            }
        ],
        "collection": [
            {
                "href": "https:\/\/www.alivitpharm.com\/en\/wp-json\/wp\/v2\/pages"
            }
        ],
        "about": [
            {
                "href": "https:\/\/www.alivitpharm.com\/en\/wp-json\/wp\/v2\/types\/page"
            }
        ],
        "author": [
            {
                "embeddable": true,
                "href": "https:\/\/www.alivitpharm.com\/en\/wp-json\/wp\/v2\/users\/9"
            }
        ],
        "replies": [
            {
                "embeddable": true,
                "href": "https:\/\/www.alivitpharm.com\/en\/wp-json\/wp\/v2\/comments?post=14463"
            }
        ],
        "version-history": [
            {
                "count": 17,
                "href": "https:\/\/www.alivitpharm.com\/en\/wp-json\/wp\/v2\/pages\/14463\/revisions"
            }
        ],
        "predecessor-version": [
            {
                "id": 14486,
                "href": "https:\/\/www.alivitpharm.com\/en\/wp-json\/wp\/v2\/pages\/14463\/revisions\/14486"
            }
        ],
        "wp:attachment": [
            {
                "href": "https:\/\/www.alivitpharm.com\/en\/wp-json\/wp\/v2\/media?parent=14463"
            }
        ],
        "curies": [
            {
                "name": "wp",
                "href": "https:\/\/api.w.org\/{rel}",
                "templated": true
            }
        ]
    }
}