{"id":13830,"date":"2026-02-02T10:20:02","date_gmt":"2026-02-02T08:20:02","guid":{"rendered":"https:\/\/www.alivitpharm.com\/?page_id=13830"},"modified":"2026-02-02T14:23:30","modified_gmt":"2026-02-02T12:23:30","slug":"myo-inositol-d-chiro-inositol","status":"publish","type":"page","link":"https:\/\/www.alivitpharm.com\/sq\/myo-inositol-d-chiro-inositol\/","title":{"rendered":"Myo-Inositol dhe D-Chiro-Inositol"},"content":{"rendered":"
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Myo-Inositol dhe D-Chiro-Inositol<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cikloheksaneksol<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Myo-inositol<\/strong>, i njohur edhe si inozitol (cikloheksanheksol), \u00ebsht\u00eb nj\u00eb karbohidrat ciklik me gjasht\u00eb grupe hidroksil. P\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb \u00ebsht\u00eb konsideruar si vitamin\u00eb B (vitamina B8). Megjithat\u00eb, nuk konsiderohet nj\u00eb l\u00ebnd\u00eb ushqyese thelb\u00ebsore sepse formohet nga glukoza. \u00c7do veshk\u00eb prodhon rreth 2 g mio-inozitol n\u00eb dit\u00eb, dhe marrja mesatare dietike \u00ebsht\u00eb 0.5\u20131.0 g\/dit\u00eb. M\u00ebl\u00e7ia dhe truri gjithashtu sintetizojn\u00eb mio-inozitol, megjith\u00ebse n\u00eb sasi shum\u00eb m\u00eb t\u00eb vogla krahasuar me veshkat. Megjithat\u00eb, \u00ebsht\u00eb e r\u00ebnd\u00ebsishme t\u00eb theksohet se n\u00eb tru, nivelet e mio-inozitolit arrijn\u00eb p\u00ebrqendrime 10 deri n\u00eb 15 her\u00eb m\u00eb t\u00eb larta se ato n\u00eb gjak. \u00cbsht\u00eb e r\u00ebnd\u00ebsishme t\u00eb theksohet se marrja e kafein\u00ebs dietike rrit nevoj\u00ebn p\u00ebr mio-inozitol. Plakja, p\u00ebrdorimi i antibiotik\u00ebve, marrja e sheqerit, mungesa e natriumit, rezistenca ndaj insulin\u00ebs dhe diabeti i tipit 1 dhe tipit 2 rrisin nevoj\u00ebn p\u00ebr mio-inozitol. Ushqimet q\u00eb p\u00ebrmbajn\u00eb shum\u00eb substanca q\u00eb formojn\u00eb inozitol, t\u00eb tilla si m\u00ebl\u00e7ia, drith\u00ebrat, farat dhe fasulet, nuk konsumohen n\u00eb sasi t\u00eb mjaftueshme. Prandaj, nga nj\u00eb perspektiv\u00eb ushqyese, marrja jon\u00eb e inozitolit \u00ebsht\u00eb shum\u00eb m\u00eb e ul\u00ebt se ajo q\u00eb njer\u00ebzit duhet t\u00eb konsumojn\u00eb.<\/p>

Mio-inozitoli dhe sindroma e vezoreve policistike: <\/strong>Sindroma e vezoreve policistike (PCOS) prek 5%\u201321% t\u00eb grave gjat\u00eb viteve t\u00eb tyre riprodhuese. Rezistenca ndaj insulin\u00ebs \u00ebsht\u00eb nj\u00eb gjetje e zakonshme tek pacient\u00ebt me PCOS, pavar\u00ebsisht nga indeksi i mas\u00ebs trupore (BMI). N\u00eb t\u00eb v\u00ebrtet\u00eb, af\u00ebrsisht 70%\u201380% e grave me PCOS dhe obezitet qendror dhe 15%\u201330% e grave t\u00eb dob\u00ebta me PCOS kan\u00eb rezistenc\u00eb ndaj insulin\u00ebs dhe hiperinsulinemi kompensuese.<\/p>

Si mio-inozitoli ashtu edhe D-kiro-inozitoli jan\u00eb t\u00eb p\u00ebrfshir\u00eb n\u00eb sinjalizimin intraqelizor t\u00eb insulin\u00ebs dhe jan\u00eb gjithashtu t\u00eb r\u00ebnd\u00ebsish\u00ebm p\u00ebr shfryt\u00ebzimin oksidativ t\u00eb glukoz\u00ebs dhe ruajtjen e saj si glikogjen.<\/p>

Enzima epimeraz\u00eb q\u00eb konverton mio-inozitolin n\u00eb D-kiro-inozitol \u00ebsht\u00eb e varur nga insulina, dhe ky konvertim \u00ebsht\u00eb i reduktuar n\u00eb indet rezistente ndaj insulin\u00ebs. Tek njer\u00ebzit me diabet t\u00eb tipit 2, ka nj\u00eb ulje t\u00eb D-kiro-inozitolit urinar dhe nj\u00eb rritje t\u00eb sekretimit t\u00eb mio-inozitolit urinar. K\u00ebshtu, nj\u00eb munges\u00eb e mio-inozitolit ose funksioni\/shprehja e d\u00ebmtuar e enzim\u00ebs q\u00eb konverton mio-inozitolin n\u00eb D-kiro-inozitol mund t\u00eb \u00e7oj\u00eb n\u00eb rezistenc\u00eb ndaj insulin\u00ebs (e cila mund t\u00eb \u00e7oj\u00eb m\u00eb tej n\u00eb nj\u00eb munges\u00eb t\u00eb D-kiro-inozitolit sepse epimeraza q\u00eb konverton mio-inozitolin n\u00eb D-kiro-inozitol \u00ebsht\u00eb e ndjeshme ndaj insulin\u00ebs).<\/p>

N\u00eb nj\u00eb prov\u00eb t\u00eb kontrolluar t\u00eb rast\u00ebsishme 12-javore n\u00eb 50 gra mbipesh\u00eb me sindrom\u00ebn e vezoreve policistike (PCOS), marrja e mio-inozitolit n\u00eb m\u00ebngjes rezultoi n\u00eb ulje t\u00eb ndjeshme t\u00eb LH (hormonit luteinizues), prolaktin\u00ebs, testosteronit, insulin\u00ebs dhe raportit LH:FSH (hormon luteinizues: hormon stimulues i folikulit) n\u00eb plazm\u00eb, dhe ndjeshm\u00ebri t\u00eb p\u00ebrmir\u00ebsuar ndaj insulin\u00ebs. Shkalla e lindjeve u p\u00ebrmir\u00ebsua gjithashtu ndjesh\u00ebm me mio-inozitol, dhe ciklet menstruale u rregulluan tek subjektet me cikle t\u00eb parregullta. P\u00ebrve\u00e7 k\u00ebsaj, Kamenov et al. zbuloi se mio-inozitoli p\u00ebrmir\u00ebsoi ovulacionin, duke \u00e7uar n\u00eb shkall\u00eb m\u00eb t\u00eb lart\u00eb shtatz\u00ebnie dhe lindjeje. U vu re gjithashtu nj\u00eb ulje e BMI-s\u00eb dhe p\u00ebrmir\u00ebsim i rezistenc\u00ebs ndaj insulin\u00ebs. Ky studim zbuloi gjithashtu se af\u00ebrsisht 61.7% e pacient\u00ebve me PCOS ovuluan pas marrjes s\u00eb mio-inozitolit. Disa meta-analiza t\u00eb provave t\u00eb kontrolluara t\u00eb rast\u00ebsishme kan\u00eb treguar se monoterapia me mio-inozitol, dhe kur kombinohet me D-kiro-inozitol, \u00ebsht\u00eb efektive n\u00eb pacient\u00ebt me PCOS.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Gjendjet rezistente ndaj insulin\u00ebs \u00e7ojn\u00eb n\u00eb rritje t\u00eb humbjes urinare t\u00eb mio-inozitolit, kryesisht p\u00ebr shkak t\u00eb frenimit t\u00eb nd\u00ebrmjet\u00ebsuar nga glukoza t\u00eb reabsorbimit t\u00eb mio-inozitolit n\u00eb veshka. Nj\u00eb ulje e mio-inozitolit zvog\u00eblon D-kiro-inozitolin, me munges\u00ebn e t\u00eb dyjave q\u00eb kontribuon n\u00eb rezistenc\u00ebn ndaj insulin\u00ebs n\u00eb muskujt skeletor\u00eb, m\u00ebl\u00e7in\u00eb dhe qelizat dhjamore. Mio-inozitoli \u00ebsht\u00eb i p\u00ebrfshir\u00eb n\u00eb fertilitet, oogjenez\u00eb, embriogjenez\u00eb, procese rigjeneruese (kontroll transkriptiv, eksportim i ARNm-s\u00eb dhe riparim i ADN-s\u00eb) dhe metaboliz\u00ebm t\u00eb yndyr\u00ebs. Mio-inozitoli pengon thithjen e glukoz\u00ebs n\u00eb duodenum dhe zvog\u00eblon rritjen e glukoz\u00ebs n\u00eb gjak.<\/p>

Anomalit\u00eb n\u00eb raportin e mio-inozitolit me D-kiro-inozitolin n\u00eb plazm\u00eb dhe urin\u00eb mund t\u00eb jen\u00eb nj\u00eb sh\u00ebnues i hersh\u00ebm i rezistenc\u00ebs ndaj insulin\u00ebs dhe diabetit t\u00eb tipit 2. P\u00ebr m\u00eb tep\u00ebr, mungesa e mio-inozitolit p\u00ebrkeq\u00ebson rezistenc\u00ebn ndaj insulin\u00ebs. Komponimet e inozitolit gjithashtu zvog\u00eblojn\u00eb hiperglicemin\u00eb n\u00eb nj\u00eb m\u00ebnyr\u00eb t\u00eb varur nga doza dhe nxisin ruajtjen e glikogjenit n\u00eb muskuj.<\/p>

Konvertimi i mio-inozitolit n\u00eb D-kiro-inozitol d\u00ebmtohet r\u00ebnd\u00eb nga rezistenca ndaj insulin\u00ebs n\u00eb indet e ndjeshme ndaj insulin\u00ebs (muskujt, indin dhjamor dhe m\u00ebl\u00e7in\u00eb). Prandaj, nj\u00eb raport i ul\u00ebt D-kiro-inozitol: mio-inozitol mund t\u00eb jet\u00eb nj\u00eb mas\u00eb e rezistenc\u00ebs ndaj insulin\u00ebs. N\u00eb t\u00eb v\u00ebrtet\u00eb, nivelet e ul\u00ebta t\u00eb D-kiro-inozitolit jan\u00eb tipike n\u00eb urin\u00eb dhe indin muskulor t\u00eb pacient\u00ebve me diabet t\u00eb tipit 2. Mungesa e mio-inozitolit do t\u00eb zvog\u00ebloj\u00eb nivelet e D-kiro-inozitolit dhe do t\u00eb p\u00ebrkeq\u00ebsoj\u00eb rezistenc\u00ebn ndaj insulin\u00ebs. N\u00eb vendet e komplikacioneve mikrovaskulare diabetike (veshkat, nervat, syt\u00eb), shpesh v\u00ebrehet nj\u00eb r\u00ebnie e nj\u00ebkohshme e mio-inozitolit intraqelizor dhe akumulimi i sorbitolit intraqelizor, prandaj suplementimi i mio-inozitolit \u00ebsht\u00eb i justifikuar tek pacient\u00ebt e diagnostikuar me diabet.<\/p>

Mio-inozitoli n\u00eb nj\u00eb doz\u00eb prej 2 g dy her\u00eb n\u00eb dit\u00eb zvog\u00eblon incidenc\u00ebn e diabetit gestacional. K\u00ebto studime vun\u00eb re gjithashtu k\u00ebrkesa t\u00eb reduktuara p\u00ebr insulin\u00eb, lindje t\u00eb vona dhe m\u00eb pak episode t\u00eb hipoglicemis\u00eb neonatale.<\/p>

\u00cbsht\u00eb e r\u00ebnd\u00ebsishme q\u00eb preparati t\u00eb ket\u00eb nj\u00eb raport t\u00eb p\u00ebrcaktuar sakt\u00ebsisht t\u00eb mio-inozitolit me D-kiro-inozitolin, pasi ato ushtrojn\u00eb nj\u00eb efekt sinergjik, i cili \u00ebsht\u00eb shum\u00eb i r\u00ebnd\u00ebsish\u00ebm p\u00ebr trajtimin e sindrom\u00ebs s\u00eb vezoreve policistike, dhe preparatet m\u00eb t\u00eb mira jan\u00eb ato q\u00eb p\u00ebrmbajn\u00eb mio-inozitol: D-kiro-inozitol n\u00eb nj\u00eb raport prej 40:1, i cili plot\u00ebsohet nga preparati Ovarinova.<\/p>

Mio-inozitoli duhet t\u00eb merret n\u00eb konsiderat\u00eb tek pacient\u00ebt me rezistenc\u00eb ndaj insulin\u00ebs, sindrom\u00eb metabolike, diabet tip 1, diabet tip 2, PCOS, dhe tek ata me diabet gestacional ose ata n\u00eb rrezik p\u00ebr t\u00eb. Nivelet e larta t\u00eb glukoz\u00ebs zvog\u00eblojn\u00eb nivelet e mio-inozitolit n\u00eb inde dhe rrisin zb\u00ebrthimin dhe eliminimin e tij nga veshkat. Mio-inozitoli \u00ebsht\u00eb p\u00ebrdorur n\u00eb m\u00ebnyr\u00eb t\u00eb sigurt p\u00ebr dekada n\u00eb shum\u00eb studime tek njer\u00ebzit me rezistenc\u00eb ndaj insulin\u00ebs dhe sindrom\u00eb t\u00eb vezoreve policistike.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Referencat<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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