{"id":14404,"date":"2026-05-20T15:12:51","date_gmt":"2026-05-20T13:12:51","guid":{"rendered":"https:\/\/www.alivitpharm.com\/?page_id=14404"},"modified":"2026-05-25T10:43:53","modified_gmt":"2026-05-25T08:43:53","slug":"quercetin-dihydroquercetin","status":"publish","type":"page","link":"https:\/\/www.alivitpharm.com\/sq\/quercetin-dihydroquercetin\/","title":{"rendered":"Kuercetin\u00eb dhe Dihidrokuercetin\u00eb"},"content":{"rendered":"
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Kuercetin\u00eb dhe Dihidrokuercetin\u00eb<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Soforetin\u00eb dhe Taksifolin\u00eb<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Kuercetina<\/strong> \u00ebsht\u00eb nj\u00eb flavonoid me veti anti-inflamatore dhe antioksiduese.<\/span><\/span><\/p>

Kuercetina \u00ebsht\u00eb nj\u00eb flavonoid me origjin\u00eb bimore i pranish\u00ebm n\u00eb shum\u00eb ushqime, i klasifikuar n\u00eb kategorit\u00eb bimore kardiovaskulare, ORL, onkologjike dhe urologjike.<\/span><\/span> Ajo ka efekte anti-inflamatore dhe antioksiduese dhe inhibon aldose reduktaz\u00ebn n\u00eb thjerr\u00ebz\u00ebn e syrit, duke u p\u00ebrdorur p\u00ebr parandalimin e katarakt\u00ebs diabetike.<\/span><\/span><\/p>

Suplementimi me kuercetin\u00eb rekomandohet p\u00ebr:<\/span>
<\/span><\/span>\u2013 Alergji sezonale;
<\/span><\/span>\u2013 Parandalimin e katarakt\u00ebs diabetike;
<\/span><\/span>\u2013 Infeksione virale;
<\/span><\/span>\u2013 S\u00ebmundje kardiovaskulare;
<\/span><\/span>\u2013 Terapi shtes\u00eb n\u00eb kancer;
<\/span><\/span>\u2013 Prostatit kronik dhe cistit intersticial;<\/span><\/span><\/p>

Studimet klinike mb\u00ebshtesin \u201cefikasitet t\u00eb mundsh\u00ebm\u201d vet\u00ebm p\u00ebr prostatitin kronik jo-bakterial dhe cistitin intersticial;<\/span><\/span> indikacionet e tjera mb\u00ebshteten kryesisht nga t\u00eb dh\u00ebnat e studimeve n\u00eb kafsh\u00eb. Nj\u00eb meta-analiz\u00eb e vitit 2023 e 12 studimeve n\u00eb kafsh\u00eb zbuloi se kuercetina p\u00ebrmir\u00ebsoi ndjesh\u00ebm gjendjen e k\u00ebrcit, duke mb\u00ebshtetur nj\u00eb efekt mbrojt\u00ebs t\u00eb k\u00ebrcit n\u00eb osteoartritin eksperimental.<\/span><\/span><\/p>

Shmangni p\u00ebrdorimin e nj\u00ebkohsh\u00ebm me digoksin\u00eb (nj\u00eb glikozid kardiak).<\/span><\/span> The safety of long-term use of high doses is unknown.<\/span><\/span> Siguria e p\u00ebrdorimit afatgjat\u00eb t\u00eb dozave t\u00eb larta nuk dihet. \u00cbsht\u00eb raportuar nefrotoksicitet me doza t\u00eb larta intravenoze.<\/span><\/span><\/p>

Shtatz\u00ebnia dhe laktacioni:<\/strong> Shmangni dozat q\u00eb tejkalojn\u00eb nivelet e suplementeve ushqimore p\u00ebr shkak t\u00eb munges\u00ebs s\u00eb t\u00eb dh\u00ebnave t\u00eb siguris\u00eb tek grat\u00eb shtatz\u00ebna dhe ato q\u00eb ushqejn\u00eb me gji.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dihidrokuercetina<\/strong> (taksifolina) \u00ebsht\u00eb nj\u00eb flavonoid i fuqish\u00ebm q\u00eb gjendet n\u00eb qep\u00eb, n\u00eb l\u00ebvoren e tamariskut francez, n\u00eb gjemba\u00e7in e qum\u00ebshtit dhe n\u00eb farat e tamarindit.<\/span><\/span> Shum\u00eb studime p\u00ebrqendrohen n\u00eb potencialin terapeutik t\u00eb dihidrokuercetin\u00ebs n\u00eb s\u00ebmundje t\u00eb m\u00ebdha si kanceri, s\u00ebmundjet kardiovaskulare dhe s\u00ebmundjet e m\u00ebl\u00e7is\u00eb<\/strong>, duke analizuar mekanizmat e propozuar t\u00eb veprimit, p\u00ebrfshir\u00eb aktivizimin e elementit t\u00eb p\u00ebrgjigjes antioksiduese dhe detoksifikimin e enzimave t\u00eb faz\u00ebs II, inhibimin e citokromit P(450) dhe sintetaz\u00ebs s\u00eb acideve yndyrore n\u00eb kancerogjenez\u00eb.<\/span><\/span> Gjithashtu shqyrtohen TNF-alfa dhe transkriptimi i varur nga NF-\u03baB n\u00eb infeksionin me hepatit C, efekti i neutralizimit t\u00eb specieve reaktive t\u00eb azotit q\u00eb rrjedhin nga mieloperoksidaza dhe efektet pasuese n\u00eb biosintez\u00ebn e kolesterolit, si dhe efektet mbi apoB\/apoA-I, HMG-CoA reduktaz\u00ebn dhe apoptoz\u00ebn.<\/span><\/span> Diskutohen gjithashtu stereokimia dhe efektet pro-oksiduese t\u00eb dihidrokuercetin\u00ebs.<\/span><\/span> Edhe pse shumica e k\u00ebrkimeve deri m\u00eb tani jan\u00eb fokusuar n\u00eb identifikimin e objektivave molekulare in vitro, ekzistojn\u00eb p\u00ebrmbledhje q\u00eb kan\u00eb p\u00ebrmbledhur provat mbi fuqin\u00eb dhe mekanizmin e veprimit t\u00eb dihidrokuercetin\u00ebs dhe kan\u00eb sugjeruar nj\u00eb rol p\u00ebr potencialin terapeutik t\u00eb antioksidant\u00ebve flavonoid\u00eb.<\/span><\/span><\/p>

Taksifolin\u00eb (dihidrokuercetina) ka treguar aktivitete farmakologjike premtuese n\u00eb trajtimin e inflamacioneve, tumoreve, infeksioneve mikrobike, stresit oksidativ, \u00e7rregullimeve kardiovaskulare dhe t\u00eb m\u00ebl\u00e7is\u00eb<\/strong>.<\/span><\/span> Aktiviteti antikancerogjen ishte m\u00eb i theksuar se aktivitetet e tjera t\u00eb vler\u00ebsuara n\u00eb modele t\u00eb ndryshme in vitro dhe in vivo<\/strong>.<\/span><\/span><\/p>

Dihidrokuercetina dhe s\u00ebmundjet e m\u00ebl\u00e7is\u00eb:<\/strong> Hulumtimi i vetive terapeutike t\u00eb dihidrokuercetin\u00ebs n\u00eb \u00e7rregullimet hepatologjike \u00ebsht\u00eb ndoshta m\u00eb intuitivi nga nj\u00ebra an\u00eb dhe m\u00eb pak i eksploruari nga ana tjet\u00ebr.<\/span><\/span> Dihidrokuercetina \u00ebsht\u00eb flavonoidi i vet\u00ebm i gjetur n\u00eb ila\u00e7in hepatoprotektiv t\u00eb licencuar Silymarin (Legalon\u00ae), i p\u00ebrdorur p\u00ebr trajtimin e d\u00ebmtimeve toksike t\u00eb m\u00ebl\u00e7is\u00eb dhe si terapi shtes\u00eb n\u00eb s\u00ebmundjet kronike inflamatore t\u00eb m\u00ebl\u00e7is\u00eb dhe cirroz\u00ebn hepatike.<\/span><\/span><\/p>

Dihidrokuercetina n\u00eb s\u00ebmundjet kardiovaskulare:<\/strong> Ashtu si n\u00eb patologjin\u00eb e kancerit, sinteza e acideve yndyrore me zinxhir t\u00eb gjat\u00eb \u00ebsht\u00eb thelb\u00ebsore p\u00ebr ruajtjen e nj\u00eb sistemi kardiovaskular funksional p\u00ebrmes riparimit t\u00eb membranave dhe prodhimit t\u00eb energjis\u00eb.<\/span><\/span> Nj\u00eb nga faktor\u00ebt kryesor\u00eb t\u00eb rrezikut p\u00ebr zhvillimin e s\u00ebmundjes koronare t\u00eb zemr\u00ebs \u00ebsht\u00eb niveli i lart\u00eb i kolesterolit LDL (lipoproteina me densitet t\u00eb ul\u00ebt).<\/span><\/span> Kjo luan nj\u00eb rol ky\u00e7 n\u00eb zhvillimin e ateroskleroz\u00ebs, nd\u00ebrsa dihidrokuercetina redukton aktivitetin e nj\u00eb enzime t\u00eb r\u00ebnd\u00ebsishme n\u00eb sintez\u00ebn e kolesterolit LDL.<\/span><\/span><\/p>

Dihidrokuercetina \u2013 objektiva molekulare p\u00ebr terapin\u00eb e kancerit:<\/strong> Numri m\u00eb i madh i publikimeve p\u00ebr dihidrokuercetin\u00ebn n\u00eb vitet e fundit lidhet me efektin e saj n\u00eb modelet e qelizave kancerogjene dhe parandalimin e efekteve t\u00eb lidhura me toksicitetin e barnave.<\/span><\/span> Ndryshimet proliferative n\u00eb qeliza, diferencimi, apoptoza, si dhe shprehja e ndryshuar e faktor\u00ebve t\u00eb transkriptimit dhe proteinave t\u00eb r\u00ebnd\u00ebsishme p\u00ebr rregullimin e ciklit qelizor, \u00e7ojn\u00eb n\u00eb zhvillimin e qelizave anormale.<\/span><\/span> Sipas studimeve t\u00eb deritanishme, dihidrokuercetina rekomandohet si suplement shtes\u00eb tek pacient\u00ebt me kancer p\u00ebr shkak t\u00eb mekanizmit t\u00eb njohur t\u00eb veprimit mbi qelizat kancerogjene.<\/span><\/span><\/p>

P\u00ebrdorimi i dihidrokuercetin\u00ebs n\u00eb trajtimin e infeksioneve me COVID-19:<\/strong> Dihidrokuercetina (DHQ) \u00ebsht\u00eb nj\u00eb bioflavonoid me aktivitet t\u00eb lart\u00eb antioksidues, mbrojt\u00ebs t\u00eb kapilar\u00ebve dhe anti-inflamator.<\/span><\/span> DHQ m\u00eb par\u00eb \u00ebsht\u00eb p\u00ebrdorur p\u00ebr trajtimin e infeksionit me koronavirusin e sindrom\u00ebs respiratore t\u00eb Lindjes s\u00eb Mesme (MERS-CoV) dhe aktualisht konsiderohet si nj\u00eb rregullator potencial i stresit oksidativ si pjes\u00eb e nj\u00eb terapie shum\u00ebfunksionale p\u00ebr COVID-19.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Referencat<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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