{"id":8519,"date":"2023-02-21T10:19:02","date_gmt":"2023-02-21T08:19:02","guid":{"rendered":"https:\/\/www.alivitpharm.com\/?page_id=8519"},"modified":"2023-02-21T11:16:38","modified_gmt":"2023-02-21T09:16:38","slug":"alfa-lipoinska-kiselina","status":"publish","type":"page","link":"https:\/\/www.alivitpharm.com\/sr\/alpha-lipoic-acid\/","title":{"rendered":"Alfa-lipoinska kiselina"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"8519\" class=\"elementor elementor-8519\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-55eb493 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"55eb493\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0e99a3d\" data-id=\"0e99a3d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25a630f elementor-widget elementor-widget-heading\" data-id=\"25a630f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Alfa-lipoinska kiselina<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea32578 elementor-widget elementor-widget-image\" data-id=\"ea32578\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.alivitpharm.com\/wp-content\/uploads\/2022\/10\/pill.png\" title=\"pill\" alt=\"Pill\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5dc68f2 elementor-widget elementor-widget-text-editor\" data-id=\"5dc68f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Tioktinska kiselina<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-77db749 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"77db749\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0066087\" data-id=\"0066087\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e741d72 elementor-widget elementor-widget-text-editor\" data-id=\"e741d72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Alfa-lipoinska kiselina<\/strong> je supstanca koje se koristi kao prevencija ili pomo\u0107 u lije\u010denju mnogih hroni\u010dnih bolesti koje su povezane sa oksidativnim stresom (kao \u0161to je dijabeti\u010dka neuropatija) i na taj na\u010din usporava nastanak metaboli\u010dkog sindroma, jer se smatra jakim antioksidansom.<\/p><p><strong><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Mehanizam djelovanja:<\/span><\/span><\/strong>\u00a0<span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Postoje dva oblika alfa-lipoinske kiseline: oksidovana lipoinska kiselina i redukovana dehidro lipoinska kiselina.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Oba oblika su sposobna da neutrali\u0161u slobodne radikale, a njihov zna\u010daj se ogleda u tome da se nijedan od oblika ne mo\u017ee prevesti u slobodni radikal.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Potom, ova supstanca ima sposobnost da regeneri\u0161e druge antioksidanse u na\u0161em organizmu, kao \u0161to su vitamini C i E, a tako\u0111e ima zna\u010dajnu ulogu u sintezi glutationa. <\/span><\/span><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">U patogenezi inflamatornih stanja, alfa-lipoinska kiselina je veoma zna\u010dajna jer ispoljava i antiinflamatorni efekat, tako \u0161to inhibira sintezu faktora inflamacije, inhibira nastanak inflamatornih citokina.<\/span><\/span> \u00a0<span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Primjena ove supstance opravdana je u lije\u010denju neuropatija koje predstavaljaju komplikaciju dijabetesa tipa I i II.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Mnoge studije su zaklju\u010dile da doza alfla-lipoinske kiseline od 300mg tokom 3 mjeseca odr\u017eava i pobolj\u0161ava vid kod osoba oboljelih od \u0161e\u0107erne bolesti tipa I i II.<\/span><\/span><\/p><p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Alfa-lipoinska kiselina dostupna je u obliku oralnih farmaceutskih oblika, kao i u obliku intravenskih injekcija.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0019cec elementor-widget elementor-widget-image\" data-id=\"0019cec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.alivitpharm.com\/wp-content\/uploads\/2022\/09\/leaves.png\" title=\"leaves\" alt=\"Leaves\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f2546df elementor-widget elementor-widget-text-editor\" data-id=\"f2546df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Alchjamerova bolest je neurodegenerativni porme\u0107aj koga karakteri\u0161e smanjenje kognitivnih funkcija povezanih sa orijentacijom i pam\u0107enjem, kao i poreme\u0107aj motori\u010dkih funkcija.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Ova patologija je rezultat abnormalnog talo\u017eenja beta-amiloidnog peptida.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Disfunkcija mitohondrija igra klju\u010dnu ulogu u patogenezi Alchajmerove bolesti.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Zbog toga, alfa-lipionska kiselina je jedinjenje koje je dobro prou\u010deno i koristi se kao dodatak u lije\u010denju mnogih neurodegenerativnih bolesti, me\u0111u kojima je i Alchajmer, zbog svog antioksidativnog, antiinflamatornog i neuroprotektivnog potencijala.<\/span><\/span><\/p><p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">\u0160to se ti\u010de farmakokineti\u010dkog profila, alfa-lipionska kiselina ima brzu apsorpciju, nisku bioraspolo\u017eivost, prolazi krvno-mo\u017edanu barijeru i metabolizam joj se de\u0161ava u jetri.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Vrlo je rijetka pojava interakcije ove susptance sa drugim suplementima ili lijekovima (do sada nisu klini\u010dki dokazane interakcije), te se upotreba alfa-lipoinske kiseline smatra bezbjednom sa farmakoterapijom.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Alfa-lipoinska kiselina se smatra sigurnim dodatkom, bez nekih izra\u017eenih nuspojava.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Vrlo su oskudni podaci o primjeni ove supstance u pedijatrijskoj populaciji, u periodu trudno\u0107e i dojenja, pa bi o primjeni trebalo da se konsultujete sa svojim ljekarom ili farmaceutom.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-96c5a0c elementor-widget elementor-widget-heading\" data-id=\"96c5a0c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Reference<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4afd7a elementor-widget elementor-widget-text-editor\" data-id=\"b4afd7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31885820\/\" target=\"_blank\" rel=\"noopener\">Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer&#8217;s Disease?<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34450170\/\" target=\"_blank\" rel=\"noopener\">Decrypting the potential role of \u03b1-lipoic acid in Alzheimer&#8217;s disease<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33401674\/\" target=\"_blank\" rel=\"noopener\">Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and \u03b1-Lipoic Acid<\/a><\/li><li><a class=\"reference-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35445914\/\" target=\"_blank\" rel=\"noopener\">\u03b1-Lipoic Acid, an Organosulfur Biomolecule a Novel Therapeutic Agent for Neurodegenerative Disorders: An Mechanistic Perspective<\/a><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Alpha-Lipoic Acid Thioctic Acid Alpha-lipoic acid is a substance that is used as a prevention or aid in the treatment of many chronic diseases that are associated with oxidative stress (such as diabetic neuropathy) and thus slows down the onset of metabolic syndrome, because it is considered a strong antioxidant. Action mechanism:\u00a0There are two forms &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/www.alivitpharm.com\/sr\/alpha-lipoic-acid\/\"> <span class=\"screen-reader-text\">Alfa-lipoinska kiselina<\/span> \u041f\u0440\u043e\u0447\u0438\u0442\u0430\u0458 \u0432\u0438\u0448\u0435 &raquo;<\/a><\/p>","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"class_list":["post-8519","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.alivitpharm.com\/sr\/wp-json\/wp\/v2\/pages\/8519","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.alivitpharm.com\/sr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.alivitpharm.com\/sr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.alivitpharm.com\/sr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alivitpharm.com\/sr\/wp-json\/wp\/v2\/comments?post=8519"}],"version-history":[{"count":0,"href":"https:\/\/www.alivitpharm.com\/sr\/wp-json\/wp\/v2\/pages\/8519\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.alivitpharm.com\/sr\/wp-json\/wp\/v2\/media?parent=8519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}