Resveratrol

3,5,4′-trihidroksistilben

Resveratrol is a polyphenol with antioxidant and antiplatelet properties, studied in cardiometabolic, oncological and neurocognitive domains. Resveratrol (cis-/trans-resveratroL) is a polyphenol found in grape skins and dark red wines. The recommended oral dose is 10–200 mg/day. This substance has antioxidant, antiplatelet, antimutagenic and phytoestrogenic properties and inhibits COX-1/2 and 5-lipoxygenase. Resveratrol supplementation is recommended for atherosclerosis, hypercholesterolemia and in the prevention of cancer.

Cardiometabolic effect: Resveratrol has been shown to reduce systolic blood pressure by 8mmHg and diastolic blood pressure by 3.6mmHg compared to placebo. The use of high doses of resveratrol ≥1000 mg/day reduced fasting glucose, but had no effect on waist circumference, triglycerides and HDL-cholesterol. Also, studies have shown that in obese individuals, this substance did not significantly change body weight, did not affect BMI, total fat, but reduced waist circumference, and the supplementation period was more than 12 weeks.

Neurocognitive effect: A systematic review/meta-analysis did not find statistically significant effects of resveratrol (or grape/wine preparations) on cognitive function, mood, gray matter volume in humans, despite positive data obtained in animals.

Antiplatelet effects: Resveratrol inhibits platelet activation; in models of colon cancer, it reduced thrombosis, indicating potential antiplatelet effects in cancer-related thrombosis. These findings are preclinical and are not yet standard therapy.

The drug monographs do not list specific side effects or precautions, however:
– Contraindications: hypersensitivity.
– Pregnancy: avoid red wine as a source of resveratrol.
– Breastfeeding: safety is unknown; not recommended.
– Antiplatelet activity implies a theoretical interaction when combined with anticoagulants/antiplatelet drugs, although this is not yet official.

Overall, current human research supports benefits for blood pressure and glycemia at higher doses.

Resveratrol

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