Magnesium

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Mg

Magnesium is taken into the body through plant foods (nuts, grains) and sea fish. A significant intake of magnesium is achieved by drinking mineral water, which contains more usable magnesium than plants. Daily needs range from 50mg for babies to 300mg for adults. During pregnancy and lactation, needs increase by 150mg.

Like other electrolytes, the role of magnesium in the body is diverse and complex. Its mechanism of action depends on which organ system is involved, as well as its formulation.

Magnesium is the fourth most common cation in the body. Most magnesium is intracellular; it is the second most common intracellular cation after potassium. Magnesium plays a vital role in over 300 metabolic reactions. It includes binding to hormone receptors, muscle contraction, nerve activity, release of neurotransmitters, vasomotor tone, and cardiac excitability. It is necessary for the active transport of potassium and calcium across the cell membrane.

Because of its diverse effects on the body, magnesium is indicated for a variety of conditions. Normal serum magnesium levels are between 1.8 and 2.2 mg/dL. Hypomagnesemia (decreased plasma magnesium): a magnesium concentration of less than 1.8mg/dL.

A decrease in magnesium can result from inadequate intake, decreased renal absorption, or impaired gastrointestinal absorption. Risk factors for hypomagnesemia include individuals with gastrointestinal disease, chronic diarrhea, proton pump inhibitor therapy, alcohol use disorder, and use of diuretics, both loop diuretics and thiazide diuretics. It is common to see hypomagnesemia in conjunction with low levels of other electrolytes, such as hypokalemia (decreased plasma potassium) and hypocalcemia (decreased plasma calcium). In patients with hypokalemia or hypocalcemia, hypomagnesemia may be the cause. Symptoms of hypomagnesemia correlate with the development of concomitant hypocalcemia. Patients may experience vague symptoms such as nausea, vomiting, lethargy, and weakness, which may indicate hypomagnesemia. Severe hypomagnesemia, less than 1.25mg/dL, may result in generalized tonic-clonic seizures.

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Indications where magnesium is recommended:

1. Eclampsia or severe preeclampsia – magnesium is given to people with severe preeclampsia to prevent seizures, and to people with eclampsia to control seizures;
2. Constipation – magnesium has a laxative effect;
3. Arrhythmias – magnesium administration is recommended for some arrhythmias;
4. Asthma – magnesium relaxes bronchial smooth muscle;
5. Migraine – hypomagnesemia has been found in patients with migraines. Magnesium supplementation is considered justified in patients suffering from migraines;

There are no contraindications for magnesium supplements with other medications. However, various medications increase or decrease magnesium concentrations, so it is important to consult a doctor or pharmacist before using any supplement. Magnesium can be used during pregnancy and breastfeeding; no risk of harm to the fetus or infant is expected based on current data.

Excessive intake of magnesium is also not safe, as it can lead to hypotension, hyporeflexia and respiratory depression.

MAGNESIUM BISGLYCINATE

Magnesium bisglycinate is a chelated form, which means that magnesium is bound to two molecules of glycine (an amino acid). This form allows for extremely good absorption in the intestines, which means that it has a much higher bioavailability than other forms of magnesium, which allows the transfer of magnesium to target tissues: muscles, bones, and the central nervous system. From glycine (the amino acid to which magnesium is bound), the body can produce glutathione (a powerful antioxidant), creatine (increases muscle strength), or collagen (needed for muscle strength and healthy bones). Magnezijum Bisglicinat Alivitpharm also contains vitamin B6, the function of which is to enhance the effects of magnesium.

Unlike some forms of magnesium (e.g. oxide, citrate), which can cause diarrhea in higher doses, bisglycinate is gentle on the digestive system. Therefore, it is ideal for people who have a sensitive gastrointestinal system or suffer from irritable bowel syndrome (IBS).

This form of magnesium is intended for:

– For professional and recreational athletes;
– For people who are tired and exhausted;
– For all people who have an increased need for magnesium (people under great psychophysical strain);
– For people who suffer from cramps (magnesium relaxes muscles);
– For sleep disorders (magnesium allows for faster sleep onset, better quality sleep, reduction of cortisol (stress hormone), increases melatonin concentration (sleep hormone));

Magnesium also has antioxidant effects, reduces the concentration of inflammatory cytokines (anti-inflammatory effect) and has a positive effect on lipid status.

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