Alpha-Lipoic Acid

Pill

Thioctic Acid

Alpha-lipoic acid is a substance that is used as a prevention or aid in the treatment of many chronic diseases that are associated with oxidative stress (such as diabetic neuropathy) and thus slows down the onset of metabolic syndrome, because it is considered a strong antioxidant.

Action mechanism: There are two forms of alpha-lipoic acid: oxidized lipoic acid and reduced dehydro lipoic acid. Both forms are capable of neutralizing free radicals, and their importance is reflected in the fact that neither form can be converted into a free radical. Then, this substance has the ability to regenerate other antioxidants in our body, such as vitamins C and E, and also has a significant role in the synthesis of glutathione. In the pathogenesis of inflammatory conditions, alpha-lipoic acid is very important because it exhibits an anti-inflammatory effect by inhibiting the synthesis of inflammatory factors, inhibiting the formation of inflammatory cytokines.  The use of this substance is justified in the treatment of neuropathies that are a complication of type I and type II diabetes. Many studies have concluded that a dose of alpha-lipoic acid of 300mg for 3 months maintains and improves vision in people suffering from both type I and type II diabetes.

Alpha-lipoic acid is available in the form of oral pharmaceutical forms, as well as in the form of intravenous injections.

Leaves

Alzheimer’s disease is a neurodegenerative disorder characterized by a decrease in cognitive functions related to orientation and memory, as well as a disorder of motor functions. This pathology is the result of abnormal deposition of beta-amyloid peptide. Mitochondrial dysfunction plays a key role in the pathogenesis of Alzheimer’s disease. Therefore, alpha-lipoic acid is a compound that has been well studied and is used as an adjunct in the treatment of many neurodegenerative diseases, including Alzheimer’s, due to its antioxidant, anti-inflammatory and neuroprotective potential.

Regarding the pharmacokinetic profile, alpha-lipoic acid has rapid absorption, low bioavailability, crosses the blood-brain barrier and is metabolized in the liver. It is very rare for this substance to interact with other supplements or drugs (so far no interactions have been clinically proven), so the use of alpha-lipoic acid is considered safe with pharmacotherapy. Alpha-lipoic acid is considered a safe supplement, without any pronounced side effects. There is very little data on the use of this substance in the pediatric population, during pregnancy and breastfeeding, so you should consult your doctor or pharmacist about its use.

References

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